They initially believed the heart to be a weirdly shaped rock, and it appeared to be there for some time. NBC affiliate WSMV in Nashville reported that the discovery was made as workers retrieved salt from their barn. The bureau’s investigation into how a human heart ended up at the salt depot and whether it was the result of a crime was “active and ongoing”, the agency added. “Additional DNA testing will be performed to try to determine its origin.” These novel numerical methods are expected to impact a broad range of fields well beyond the project.“An initial examination of the heart determined that it was that of an adult male,” the Tennessee bureau of investigation said in a statement. To provide these novel insights requires new coupled simulation approaches.Īccordingly, the project aims to create a new class of monolithic finite volume fluid-electrosolid interaction methods, which can provide predictions in clinically relevant timescales through the exploitation of hybrid CPU-GPU systems. It is targeting the establishment of the first family of porcine cardiac xenotransplant models that can provide clinically significant insights into the haemodynamic compatibility of porcine donor hearts, the impact of surgical approach, and the consequence of pathologies. XenoSim aims to address these challenges by providing fundamental clinical insights into the nascent field of cardiac xenotransplantation through the development of novel high-resolution, higher-order, multiphysics simulation methods. To overcome these requires a deep understanding of the physiological and mechanical challenges introduced by xenotransplants. And this backing above all gives them a chance to pursue their scientific dreams,” said Professor Maria Leptin, ERC President.Ĭross-species transplants, or xenotransplantation, has long been a dream for clinicians as a means to address organ shortages.Īnd while rapid progress in gene editing has made the concept possible, barriers such as rejection, immunity and infection remain. “ERC Consolidator grants support researchers at a crucial time of their careers, strengthening their independence, reinforcing their teams and helping them establish themselves as leaders in their fields. The XenoSim team will employ three Postdoctoral researchers, three PhD students and one Research Assistant. Worth €657 million in total, the grants will create some 1950 jobs for postdoctoral fellows, PhD students, and other staff at host institutions around Europe. The competitive ERC Consolidator Grants are awarded to researchers to pursue their most promising ideas. “This pioneering research promises to offer not only unprecedented insights into the cutting-edge realm of cardiac xenotransplantation but also to establish pioneering computational techniques with significant implications for a wide range of scientific disciplines.” “With the support of this ERC Consolidator grant, we aim to unlock invaluable insights into these differences by developing advanced biomechanical computational models. From an engineering standpoint, pig hearts share similarities with their human counterparts in terms of ‘pump design’ however, their distinct size, shape, and functional characteristics introduce important differences that can impact their performance within the human body,” said Dr Cardiff, who is the Director of the Bekaert University Technology Centre at UCD and a funded investigator at I-Form, the SFI National Research Centre for Advanced Manufacturing. "We stand on the threshold of a groundbreaking medical era where pig-to-human heart transplants are becoming a reality.
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